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Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

Cardiac and renal problemsPrednisone can increase blood pressurecause water and sodium retentionand increase potassium and calcium excretionTell your doctor if you have a history of heart or kidney disease.

The diurnal rhythm of the HPA axis is lost in Cushing’s diseasea syndrome of adrenocortical hyperfunction characterized by obesity with centripetal fat distributionthinning of the skin with easy bruisabilitymuscle wasting with weaknesshypertensionlatent diabetesosteoporosiselectrolyte imbalanceetcThe same clinical findings of hyperadrenocorticism may be noted during long-term pharmacologic dose corticoid therapy administered in conventional daily divided dosesIt would appearthenthat a disturbance in the diurnal cycle with maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effectsEscape from these constantly elevated plasma levels for even short periods of time may be instrumental in protecting against undesirable pharmacologic effects.

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